|Year : 2021 | Volume
| Issue : 3 | Page : 97-103
A Retrospective analysis of biosimilar and reference trastuzumab in human epidermal growth factor receptor-2 positive early and/or locally advanced breast cancer patients treated with neoadjuvant-adjuvant setting: Safety and event-free survival outcomes
Rahul Kulkarni1, Shriniwas Kulkarni1, Almas Pathan2, Shona Nag1
1 Department of Medical Oncology, Sahyadri Hospital, Pune, Maharashtra, India
2 Department of Family Medicine, Sahyadri Hospital, Pune, Maharashtra, India
|Date of Submission||16-Jun-2021|
|Date of Decision||09-Aug-2021|
|Date of Acceptance||25-Oct-2021|
|Date of Web Publication||14-Dec-2021|
6727, Sahyadri Super Speciality Hospitals, Maharashtra State Electricity Board, Nagar Rd, Hermes Heritage Society Phase 1, Shastrinagar, Yerawada, Pune - 411 006, Maharashtra
Source of Support: None, Conflict of Interest: None
Background: There is limited real-world evidence on the treatment outcomes with Trastuzumab, specifically with biosimilars. This analysis aims to evaluate the safety and effectiveness of Trastuzumab in early and/or locally advanced breast cancer patients treated with neoadjuvant-adjuvant treatment in the real world setting and to compare biosimilar with reference trastuzumab. Materials and Methods: We retrospectively analyzed the data of patients with human epidermal growth factor receptor-2 (HER-2)-positive breast cancers, who were treated with trastuzumab-based standard therapies. The survival curves were generated using the Kaplan–Meier method. Event-free survival (EFS) was calculated. All patients were assessed for toxicity as per CTCAE version 4.0. The subgroup analysis was carried out to compare the effectiveness of biosimilar with reference trastuzumab. Results: A total of 88 patients were evaluated from 2008 to 2018. EFS at 1, 2, and 5-year was 89.5%, 78%, and 44.2%, respectively. The median EFS was 43 months. In subgroup analysis, the 1, 2-, and 3-year EFS rates were 86.7%, 86.7%, and 57.8%, respectively, for reference Trastuzumab (n = 29) as compared to 91%, 74.4%, and 56.9%, respectively, for Biosimilar Trastuzumab (n = 59). Similarly, median EFS was 43 months and not reached, respectively. There was no significant difference in EFS between the two groups (P = 0.991). A significant asymptomatic decrease in the left ventricular ejection fraction (LVEF) of ≥10% to below the lower limit of normal was noted in only two patients (2.3%). There was no significant difference observed in reduction of LVEF to below the lower limit of normal between the two groups (P = 0.514). The common grade 3/4 adverse events (AEs) observed such as vomiting, diarrhea, pancytopenia, and anemia were mostly due to chemotherapy. These AEs were comparable in both groups. Conclusions: The EFS in our study is consistent with the historical data. Safety and effectiveness of biosimilars were comparable to the reference transtuzumab.
Keywords: Adjuvant, biosimilar, human epidermal growth factor receptor-2 positive breast cancer, neoadjuvant, trastuzumab
|How to cite this article:|
Kulkarni R, Kulkarni S, Pathan A, Nag S. A Retrospective analysis of biosimilar and reference trastuzumab in human epidermal growth factor receptor-2 positive early and/or locally advanced breast cancer patients treated with neoadjuvant-adjuvant setting: Safety and event-free survival outcomes. Oncol J India 2021;5:97-103
|How to cite this URL:|
Kulkarni R, Kulkarni S, Pathan A, Nag S. A Retrospective analysis of biosimilar and reference trastuzumab in human epidermal growth factor receptor-2 positive early and/or locally advanced breast cancer patients treated with neoadjuvant-adjuvant setting: Safety and event-free survival outcomes. Oncol J India [serial online] 2021 [cited 2022 Jul 6];5:97-103. Available from: https://www.ojionline.org/text.asp?2021/5/3/97/332507
| Introduction|| |
Globally, breast cancer is the most common female cancer, accounting for almost 24.5% of all cancers in women. India faces a challenging situation due to a rise in cancer-associated morbidity and mortality from breast cancer. Human epidermal growth factor receptor-2 (HER-2) overexpression and gene amplification are present in around 15%–20% of breast cancers and are associated with increased aggressive clinical behavior, early systemic metastasis, poor prognosis, and decreased survival outcomes. The development of novel and effective HER-2 targeted therapies has significantly improved the treatment outcomes of patients with HER-2-positive breast cancer.
The addition of HER-2 targeted therapies significantly improves tumor response and survival function in adjuvant, neoadjuvant, and metastatic settings compared to chemotherapy alone in this subtype of patients. Trastuzumab is a humanized monoclonal antibody that binds to the extracellular domain of the HER-2 transmembrane growth factor receptor. Several clinical trials have shown that treating HER-2 positive metastatic breast cancer with Trastuzumab, either alone or in combination with chemotherapy, significantly improves treatment outcomes.,,,,, Similarly, Trastuzumab has been shown to be an effective adjuvant therapy for HER2-positive early stage breast cancer patients.,,,, In the neoadjuvant setting, randomized trials have shown that more patients achieved a pathological complete response with the addition of Trastuzumab to chemotherapy.,,, Despite the overall encouraging efficacy and safety profile of Trastuzumab, cardiotoxicity has emerged as an adverse effect that is generally consistent throughout clinical trials., Therefore, the need for long-term data assessment on the safety profile and real-world effectiveness in daily clinical practice is essential.
Owing to the high cost anti-HER2 targeted therapy, only 8.41%−35.85% of eligible patients are able to receive it in the Indian setting.,, With the advent of different Trastuzumab biosimilars, there has been a rapid increase in the use of Trastuzumab for the treatment of HER-2-positive breast cancer in clinical practice. However, several barriers such as high and differential cost between generics, insufficient evidence on long-term safety and effectiveness of biosimilars remain. The present study retrospectively assessed the real-world patterns of usage and treatment outcomes of Trastuzumab (biosimilars or Reference) in neoadjuvant and adjuvant setting for HER-2-positive breast cancer along with the comparison of biosimilar with reference Trastuzumab.
| Materials and Methods|| |
This was a retrospective study carried out at a tertiary oncology hospital in Pune, India. The analysis was based on the data extracted from patient's hospital/medical records treated from 2008 until 2018. The data were retrospectively collected in accordance with good clinical practice principles.
We retrospectively reviewed the records of histopathological confirmed cases of breast cancer patients treated for HER-2-positive breast cancer. The patients included in this analysis were selected based on the following criteria: age ≥18 years; histologically confirmed diagnosis of breast cancer; had early and/or locally advanced; had been diagnosed as HER-2 positive by immunohistochemistry (IHC) and/or positive fluorescence in situ hybridization (FISH) test; and had undergone surgery for breast cancer and received neoadjuvant and/or adjuvant standard chemotherapy therapy with trastuzumab (either biosimilar or reference).
Data of each patient were collected, which included demographic details, clinical details, imaging findings, histopathological reports, IHC and FISH reports, Echocardiography reports, clinical course, surgical/operative details, and details of drug therapies including neoadjuvant-adjuvant chemotherapy and trastuzumab therapy (including biosimilars).
IHC done for the cases to evaluate estrogen receptor, progesterone receptor, HER2 neu receptor, and Ki67 status. In cases of HER2 neu equivocal result (2+) repeat IHC or FISH study was applied for confirmation of HER2 neu status.
Echocardiography data were captured retrospectively at baseline and posttreatment. Left ventricle ejection fraction (LVEF) value was recorded from each echocardiography report.
Transtuzumab was used along with chemotherapy in neoadjuvant and/or adjuvant settings and also used as maintenance therapy. The various chemotherapeutic drugs such as taxane, anthracycline, 5FU, and cyclophosphamide were used in different combination regimens. As per the hospital protocol, majority of patients received trastuzumab on weekly cycle basis and some patients were treated with 3 weekly trastuzumab as per their convenience. Weekly transtuzumab was given as 4 mg/kg body weight (mg/kg) in the first cycle followed by 2 mg/kg in subsequent cycles, whereas 3 weekly transtuzumab was given as 8 mg/kg in first cycle followed by 6 mg/kg in subsequent cycles. All the maintenance transtuzumab was given as 3 weekly cycles.
The outcome of treatment was analyzed as effectiveness of treatment in terms of event-free survival (EFS) and toxicity profile. EFS was defined as time from the date of start of therapy to the date of disease recurrence or progression (local, regional, distant, or contralateral), or last follow-up (censored) or death from any cause, whichever occurred first.
Toxicity data were assessed using the National Cancer Institute Common Terminology Criteria for adverse events (NCI CTCAE) version 4. Change in the LVEF from baseline to posttrastuzumab treatment was evaluated. An absolute asymptomatic decline in LVEF of ≥10% to below the lower limit of normal is considered significant.
Effectiveness in terms of EFS rates and safety was compared between the biosimilar and reference trasrtuzumab.
Statistical Package for the Social Sciences IBM SPSS Statistics for Windows, Version 21.0 Armonk, New York (USA): IBM Corp. software version 21.0 was used for the statistical analyses. Descriptive statistics were used to express the data. The survival curves were generated using the Kaplan − Meier method. The probability (P) value for the comparison of survival function between the groups was obtained using the log-rank test. The association between the variables was estimated by the Chi-square test and Fisher's exact test, as appropriate. P < 0.05 was considered statistically significant.
| Results|| |
Eighty-eight patients of HER-2 positive early and/or locally advanced breast cancer treated with neoadjuvant and adjuvant standard chemotherapy and Trastuzumab were identified and analyzed. Eleven patient's data were collected from 2008 to 2013, 35 patients from 2014 to 2015, and 42 patients from 2016 to 2018.
The patient's demographic and clinical characteristics are depicted in [Table 1]. The mean age of the patients was 51.3 ± 10.3 years, and all the patients were female. KPS score ≥90 was seen in 96.6% patients. 70.5% patients had IHC 3+ and 46 (52.3%) patients had stage III disease. In the neoadjuvant-adjuvant setting (n = 88), 23 (26.1%) patients received transtuzumab treatment on neoadjuvant setting and 65 (73.9%) received in adjuvant setting. Of these patients in neoadjuvant/adjuvant trastuzumab treatment, 28 patients received <6 cycles, 26 patients received 6−11 cycles, and 34 patients received ≥12 cycles. Thirty-nine out of these 88 patients (40.9%) received maintenance trastuzumab, with an average number of cycles of 5.7 ± 2.9 and 9.6 ± 2.8 for Biosimilar and Reference trastuzumab, respectively.
Entire study population
EFS were analyzed using the Kaplan–Meier method. The 1-year, 2-year, and 5-year EFS rates for entire study population were 89.5%, 78% and 44.2%, respectively [Figure 1]. The median EFS was 43 months (95% confidence interval [CI]: 26.7–59.2).
|Figure 1: Kaplan–Meier curve for event-free survival in neoadjuvant-adjuvant setting (entire population)|
Click here to view
According to CTCAE version 4, the detailed toxicity and their grades are summarized in [Table 2]. The most common grade 3/4 AEs were vomiting (42%), diarrhea (35.2%), pancytopenia (34.1%), and anemia (30.7%). These toxicities were occurred during neoadjuvant-adjuvant treatment and were mostly due to chemotherapy induced.
A significant asymptomatic decrease in the LVEF of ≥10% to below the lower limit of normal was noted in only two patients (2.3%) after treatment completion, whereas in 15 (17.0%) patients, the decrease in the LVEF was between 5% and 9% post-trastuzumab treatment.
Biosimilar versus reference trastuzumab
Comparison analysis was done between Biosimilars and Reference transtuzumab. In this study, 29 patients received reference Trastuzumab (manufactured by Roche), and remaining 59 patients received Biosimilars. Majority of Biosimilars received were USFDA approved Biocon's Biosimilar Trastuzumab (28 patients; 47.46%) and 31 patients received multiple other Biosimilars. The general characteristics of patients in reference and Biosimilars were similar and are shown in [Table 1].
The 1-year, 2-year, and 3-year EFS rates for Biosimilar Trastuzumab (n = 59) were 91%, 74.4%, and 56.9%, respectively, whereas it was 86.7%, 86.7%, and 57.8%, respectively, for reference Trastuzumab (n = 29) [Figure 2]. The median EFS for Biosimilar Trastuzumab group was not reached as compared to 43 months for reference Trastuzumab group (95% CI: 32.4-53.5). There was no significant difference in EFS between the two groups (P = 0.991).
|Figure 2: Kaplan–Meier estimates of event-free survival in reference trastuzumab and biosimilar trastuzumab in neoadjuvant-adjuvant setting|
Click here to view
In both groups, majority of patients post treatment had a decrease in the LVEF of <5% from the lower limit of normal. The reduction in the LVEF to below the lower limit of normal between the groups was not statistically significant (P = 0.514). Grade 3/4 AEs were comparable in both groups (biosimilar vs reference trastuzumab): vomiting (40.7% vs. 44.8%), diarrhea (33.9% vs. 37.9%), pancytopenia (39.0% vs. 24.1%), and anemia (28.8% vs. 34.5%). These toxicities were mainly related to chemotherapy and not due to trastuzumab. The overall safety profile of biosimilar trastuzumab was similar in nature with reference trastuzumab and is summarized in [Table 2].
| Discussion|| |
The findings of our retrospective analysis indicate that trastuzumab-based therapies resulted in survival benefit in HER-2-positive breast cancer in neoadjuvant-adjuvant setting.
Treatment of patients with HER-2 positive breast cancer has evolved rapidly since the identification of HER-2 as a potential target for anticancer activity. Reference Trastuzumab was approved in 1998 by the USFDA and first Biosimilar Trastuzumab entered into India market in late 2013. HER-2 targeted therapies have significantly improved the treatment outcomes in HER-2 positive breast cancers. Randomized trials and meta-analysis have shown strong evidence of clinical efficacy in early,,, and metastatic,,, HER2-positive breast cancer.
Although randomized clinical trials (RCT) are the gold standard, they have limitations. The selected population enrolled in a clinical trial is not always true representative of the actual population coming into routine practice where patients have diverse ethnicity, comorbid conditions, poor clinical status, advancing age, complex interactions and financial restraint.
In this retrospective study, an attempt was made to explore the real-world treatment outcomes of Trastuzumab in HER-2-positive breast cancers and to explore the treatment outcomes between Biosimilar and Reference Trastuzumab in neoadjuvant-adjuvant setting.
In our study, the 1-year, 2-year, and 5-year EFS rates were 89.5%, 78%, and 44.2%, respectively and the median EFS was 43 months (95% CI: 26.7-59.2). The 3-year and 5-year EFS rates in NOAH trial for HER2-positive disease were 71% and 58%, respectively, in patients who received 1 year of trastuzumab (concurrently with neoadjuvant chemotherapy and continued after surgery)., HannaH clinical trial reported a 3-year EFS of 73% in patients treated with neoadjuvant-adjuvant intravenous trastuzumab. In another study by Palmieri C et al., treatment with neoadjuvant chemotherapy plus trastuzumab reported a better 5 year EFS compared to neoadjuvant chemotherapy followed by adjuvant trastuzumab (69.6% vs 59.3%). Thus, the overall results of improved EFS outcomes in our study in the neoadjuvant-adjuvant setting are in agreement with historical data.
The safety profile observed in our study is similar to the safety profile of Trastuzumab containing therapies observed in RCT. The most frequently reported AEs common to both the setting in our study were vomiting, diarrhea, pancytopenia, and anemia.
Cardiac dysfunctions (decrease in LVEF) are relatively common (2-3 times increased risk) during Trastuzumab therapy,,, but usually are reversible with interruption in or cessation of Trastuzumab therapy., It is mandatory to assess cardiovascular functions before initiation and continuously monitoring during the Trastuzumab therapy. In our study, only two patients (2.3%) had an asymptomatic significant decrease in the LVEF ≥ 10% to below the lower limit of normal with Trastuzumab therapy in the neoadjuvant-adjuvant setting. The cardiac risks are substantially declined with sequential therapy compared to concurrent administration of Trastuzumab with anthracycline-taxane-based chemotherapy.,
In the subgroup analysis, we compared biosimilar trastuzumab with reference trastuzumab. The 1, 2, and 3-year EFS rates between the biosimilar and reference trastuzumab groups were comparable. The safety profile and LVEF reduction in both the groups were comparable.
In India, around 70% of the population pay health-care expenses out of their own pockets. Owing to its high cost, cancer treatment usually exceeds per capita income by multiple folds. Gupta et al. showed that price reduction of 15% to 35% would make 1-year Trastuzumab treatment more cost effective. Globally, cost savings of up to 70% have been observed with the introduction of biosimilars, which has increased accessibility and affordability to life-saving biologics.,
Various biosimilar trastuzumab drugs are available in the market and have followed diverse pathways in their clinical development, with variations in trial design, patient population, and assessment endpoint., In order to make informed decisions in practice, it is important for the oncologist to view the totality of phase-3 clinical trial evidence and regulatory approval. Biosimilar Trastuzumab offers an alternative option to reference Trastuzumab with equivalent efficacy, safety, and immunogenicity evidence as demonstrated in phase-3 confirmatory clinical trial (Heritage Study) and also with approvals from regulatory licensing authorities, including CDSCO-India, U. S. Food and Drug Administration (US-FDA), European Medicines Agency, Health-Canada, ANVISA-Brazil and TGA-Australia.
Although the findings in our study are comparable with previous studies, there are some limitations of this retrospective analysis. This was a retrospective study performed at a single hospital. There is disparity in the number of cycles of Trastuzumab administered, heterogeneous standard therapies. Overall survival analysis could not be conducted due to inconsistencies in the available data, patients nonreporting and lost to follow-up. Despite these limitations, our retrospective studies provide a real picture of the benefits of HER2-targeted therapy in “real-world” practice.
| Conclusions|| |
Trastuzumab is a standard of care in the management of HER-2-positive breast cancer. The findings of this real-world evidence are consistent with historical data, irrespective of reference or biosimilar trastuzumab. In subgroup analysis, safety and effectiveness of biosimilar trastuzumab were comparable to the reference Trastuzumab. Hence, instead of reference trastuzumab, biosimilars because of being cost-effective can be safely practiced in developing countries like India for HER2 positive breast carcinoma patients. Further prospective studies with large sample size and longer duration of follow-up could provide better survival analysis.
We acknowledge the support provided for data cleaning and medical writing by Ramez Ahmed, Medical Affairs, Biocon Biologics Limited and statistical analysis by an independent statistician, Dr. Pradeep Jadhav.
Financial support and sponsorship
The data analysis and medical writing was sponsored by Biocon Biologics Limited.
Conflicts of interest
There are no conflicts of interest.
| References|| |
Global Cancer Observatory 2020. International Agency for Research on Cancer. World Health Organization. Available from: https://gco.iarc.fr/
. [Last accessed on 2021 Aug 10].
Malvia S, Bagadi SA, Dubey US, Saxena S. Epidemiology of breast cancer in Indian women. Asia Pac J Clin Oncol 2017;13:289-95.
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987;235:177-82.
Li SG, Li L. Targeted therapy in HER2-positive breast cancer. Biomed Rep 2013;1:499-505.
Schramm A, De Gregorio N, Widschwendter P, Fink V, Huober J. Targeted therapies in HER2-positive breast cancer – A systematic review. Breast Care (Basel) 2015;10:173-8.
Vogel CL, Cobleigh MA, Tripathy D, Gutheil JC, Harris LN, Fehrenbacher L, et al.
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 2002;20:719-26.
Slamon DJ, Leyland-Jones B, Shak S, Fuchs H, Paton V, Bajamonde A, et al.
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344:783-92.
Pegram MD, Pienkowski T, Northfelt DW, Eiermann W, Patel R, Fumoleau P, et al.
Results of two open-label, multicenter phase II studies of docetaxel, platinum salts, and trastuzumab in HER2-positive advanced breast cancer. J Natl Cancer Inst 2004;96:759-69.
Marty M, Cognetti F, Maraninchi D, Snyder R, Mauriac L, Tubiana-Hulin M, et al.
Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group. J Clin Oncol 2005;23:4265-74.
Robert N, Leyland-Jones B, Asmar L, Belt R, Ilegbodu D, Loesch D, et al.
Randomized phase III study of trastuzumab, paclitaxel, and carboplatin compared with trastuzumab and paclitaxel in women with HER-2-overexpressing metastatic breast cancer. J Clin Oncol 2006;24:2786-92.
Balduzzi S, Mantarro S, Guarneri V, Tagliabue L, Pistotti V, Moja L, et al.
Trastuzumab-containing regimens for metastatic breast cancer. Cochrane Database Syst Rev 2014;2014:CD006242.
Piccart-Gebhart MJ, Procter M, Leyland-Jones B, Goldhirsch A, Untch M, Smith I, et al.
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005;353:1659-72.
Romond EH, Perez EA, Bryant J, Suman VJ, Geyer CE Jr., Davidson NE, et al.
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005;353:1673-84.
Joensuu H, Kellokumpu-Lehtinen PL, Bono P, Alanko T, Kataja V, Asola R, et al.
Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. N Engl J Med 2006;354:809-20.
Genuino AJ, Chaikledkaew U, The DO, Reungwetwattana T, Thakkinstian A. Adjuvant trastuzumab regimen for HER2-positive early-stage breast cancer: A systematic review and meta-analysis. Expert Rev Clin Pharmacol 2019;12:815-24.
Wilson FR, Coombes ME, Brezden-Masley C, Yurchenko M, Wylie Q, Douma R, et al.
Herceptin® (trastuzumab) in HER2-positive early breast cancer: A systematic review and cumulative network meta-analysis. Syst Rev 2018;7:191.
Buzdar AU, Ibrahim NK, Francis D, Booser DJ, Thomas ES, Theriault RL, et al.
Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: Results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer. J Clin Oncol 2005;23:3676-85.
Untch M, Rezai M, Loibl S, Fasching PA, Huober J, Tesch H, et al.
Neoadjuvant treatment with trastuzumab in HER2-positive breast cancer: Results from the GeparQuattro study. J Clin Oncol 2010;28:2024-31.
Pierga JY, Delaloge S, Espié M, Brain E, Sigal-Zafrani B, Mathieu MC, et al.
A multicenter randomized phase II study of sequential epirubicin/cyclophosphamide followed by docetaxel with or without celecoxib or trastuzumab according to HER2 status, as primary chemotherapy for localized invasive breast cancer patients. Breast Cancer Res Treat 2010;122:429-37.
Gianni L, Eiermann W, Semiglazov V, Manikhas A, Lluch A, Tjulandin S, et al.
Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): A randomised controlled superiority trial with a parallel HER2-negative cohort. Lancet 2010;375:377-84.
Mohan N, Jiang J, Dokmanovic M, Wu WJ. Trastuzumab-mediated cardiotoxicity: Current understanding, challenges, and frontiers. Antib Ther 2018;1:13-7.
Ewer MS, Vooletich MT, Durand JB, Woods ML, Davis JR, Valero V, et al.
Reversibility of trastuzumab-related cardiotoxicity: New insights based on clinical course and response to medical treatment. J Clin Oncol 2005;23:7820-6.
Badwe R, Hawaldar R, Nair N, Kaushik R, Parmar V, Siddique S, et al.
Locoregional treatment versus no treatment of the primary tumour in metastatic breast cancer: An open-label randomised controlled trial. Lancet Oncol 2015;16:1380-8.
Ghosh J, Gupta S, Desai S, Shet T, Radhakrishnan S, Suryavanshi P, et al.
Estrogen, progesterone and HER2 receptor expression in breast tumors of patients, and their usage of HER2-targeted therapy, in a tertiary care centre in India. Indian J Cancer 2011;48:391-6.
] [Full text]
Adusumilli P, Konatam ML, Gundeti S, Bala S, Maddali LS. Treatment challenges and survival analysis of human epidermal growth factor receptor 2-positive breast cancer in real world. Indian J Med Paediatr Oncol 2017;38:22-7.
] [Full text]
Dang CT, Yu AF, Jones LW, Liu J, Steingart RM, Argolo DF, et al.
Cardiac surveillance guidelines for trastuzumab-containing therapy in early-stage breast cancer: Getting to the heart of the matter. J Clin Oncol 2016;34:1030-3.
Blackwell K, Gligorov J, Jacobs I, Twelves C. The global need for a trastuzumab biosimilar for patients with HER2-positive breast cancer. Clin Breast Cancer 2018;18:95-113.
Gianni L, Eiermann W, Semiglazov V, Lluch A, Tjulandin S, Zambetti M, et al.
Neoadjuvant and adjuvant trastuzumab in patients with HER2-positive locally advanced breast cancer (NOAH): Follow-up of a randomised controlled superiority trial with a parallel HER2-negative cohort. Lancet Oncol 2014;15:640-7.
Jackisch C, Hegg R, Stroyakovskiy D, Ahn JS, Melichar B, Chen SC, et al.
HannaH phase III randomised study: Association of total pathological complete response with event-free survival in HER2-positive early breast cancer treated with neoadjuvant-adjuvant trastuzumab after 2 years of treatment-free follow-up. Eur J Cancer 2016;62:62-75.
Palmieri C, Macpherson IR, Yan K, Ades F, Riddle P, Ahmed R, et al.
Neoadjuvant chemotherapy and trastuzumab versus neoadjuvant chemotherapy followed by post-operative trastuzumab for patients with HER2-positive breast cancer. Oncotarget 2016;7:13209-20.
Cameron D, Piccart-Gebhart MJ, Gelber RD, Procter M, Goldhirsch A, de Azambuja E, et al.
11 years' follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive early breast cancer: Final analysis of the HERceptin Adjuvant (HERA) trial. Lancet 2017;389:1195-205.
Untch M, Fasching PA, Konecny GE, Hasmüller S, Lebeau A, Kreienberg R, et al.
Pathologic complete response after neoadjuvant chemotherapy plus trastuzumab predicts favorable survival in human epidermal growth factor receptor 2-overexpressing breast cancer: Results from the TECHNO trial of the AGO and GBG study groups. J Clin Oncol 2011;29:3351-7.
Chopra R, Lopes G. Improving access to cancer treatments: The role of biosimilars. J Glob Oncol 2017;3:596-610.
Gupta N, Verma RK, Gupta S, Prinja S. Cost effectiveness of trastuzumab for management of breast cancer in India. JCO Glob Oncol 2020;6:205-16.
Barbier L, Declerck P, Simoens S, Neven P, Vulto AG, Huys I. The arrival of biosimilar monoclonal antibodies in oncology: Clinical studies for trastuzumab biosimilars. Br J Cancer 2019;121:199-210.
Rugo HS, Barve A, Waller CF, Hernandez-Bronchud M, Herson J, Yuan J, et al.
Effect of a proposed trastuzumab biosimilar compared with trastuzumab on overall response rate in patients with ERBB2 (HER2)-positive metastatic breast cancer: A randomized clinical trial. JAMA 2017;317:37-47.
[Figure 1], [Figure 2]
[Table 1], [Table 2]